Prof. Seunghyuk Choi 최승혁 교수
Computational Bioinformatics Lab
Contact
Phone 02-910-5653
E-mail shchoi8@kookmin.ac.kr
E-mail shchoi8@kookmin.ac.kr
Office 사무실 미래관 7층 5-1호 (02-910-5653)
Education 학력
Ph.D. Hanyang University ()
Career 경력
Present Assistant Professor, Kookmin University
현재 국민대학교 조교수
Research Overview 연구 개요
The lab focuses on decoding tumor biology and revealing new therapeutic targets by combining multi-omics approaches including mass spectrometry-based proteomics, next-generation sequencing, and advanced computational algorithms and AI models.
본 연구실은 질량분석 기반 프로테오믹스, 차세대 시퀀싱, 고급 컴퓨팅 알고리즘 및 AI 모델을 포함한 멀티오믹스 접근법을 결합하여 종양 생물학을 해독하고 새로운 치료 표적을 발굴하는 데 주력하고 있습니다.
Research Areas 연구 분야
- Computational Bioinformatics
- Proteomics
- Multi-omics
- AI for Drug Discovery
- 전산 생물정보학
- 프로테오믹스
- 멀티오믹스
- 신약 발굴을 위한 AI
Major Achievements 주요 연구 성과
- PepQueryMHC: Rapid tumor antigen prioritization from immunopeptidomics (Genome Biology 2025)
- Proteogenomic analysis reveals non-small cell lung cancer subtypes (Nature Communications 2024)
Recent Publications 주요 논문
- S. Choi and B. Zhang, "PepQueryMHC: Rapid and comprehensive tumor antigen prioritization from immunopeptidomics data," Genome Biology, 2025
- K. J. Song, M. Kim, Y. J. Heo, ..., S. Choi, ..., and M.-S. Kim, "Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability," Journal of Proteome Research, 2025
- S. Chang, R. Moon, D. Nam, ..., S. Choi, ..., and H. Park, "Hypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescence," Nucleic Acids Research, 2025
- J. Seo, S. Choi, and E. Paek, "NovoRank: Refinement for De Novo Peptide Sequencing Based on Spectral Clustering and Deep Learning," Journal of Proteome Research, 2025
- K. J. Song, S. Choi, ..., and M.-S. Kim, "Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment," Nature Communications, 2024
- S. Choi and E. Paek, "pXg: Comprehensive Identification of Noncanonical MHC-I-Associated Peptides From De Novo Peptide Sequencing Using RNA-Seq Reads," Molecular & Cellular Proteomics, 2024
- D. Y. Hyeon, D. Nam, ..., S. Choi, ..., "Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population," Nature Cancer, 2023
- S. Choi and E. Paek, "MutCombinator: identification of mutated peptides allowing combinatorial mutations using nucleotide-based graph search," Bioinformatics, 2020
- S. Oh, J. Yeom, ..., S. Choi, ..., "Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma," Nature Communications, 2020
- S. Choi, S. Ju, J. Lee, S. Na, C. Lee, and E. Paek, "Proteogenomic approach to UTR peptide identification," Journal of Proteome Research, 2020